BOMCC released for sale
The chemical 7-benzyloxymethyloxy-3-cyanocoumarin (BOMCC) is now available for purchase. BOMCC, a fluorogenic substrate chemically identical to ThermoFisher’s Vivid® BOMCC, is metabolised by a number of human CYPs, including CYP2B6, CYP2C9, CYP3A4 and CYP3A5 to yield the fluorescent metabolite 3-cyano-7-hydroxycoumarin (CHC). We have previously published data showing the usefulness of BOMCC for the screening of potential inhibitors of human CYP51.
Further details are available here.