Cypex - in vitro drug metabolism systems
Cypex - in vitro drug metabolism systems
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linksCypex - in vitro drug metabolism systems
Cypex - in vitro drug metabolism systems
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products and services                   
 

Products
Details of products and services can be found under the following headings:

Bactosomes (human CYPs)
Bactosomes (dog CYPs)
Bactosomes (mouse CYPs)
Bactosomes (monkey CYPs)
Bactosomes (pig CYPs) NEW!
Bactosomes (rat CYPs)
Other human drug-metabolising enzymes
Control preparations
Chemicals
Antibodies NEW MONOCLONALS!
Purified CYPs
NEW!

Services

Inhibition screening services NEW!

A summary of the current product range (PDF, 214k) is also available.

Enzyme products can be aliquotted / diluted to your own specification, within the limits defined by individual batch characteristics, subject to a minimum order size.

Bactosomes can be used in conjunction with the Simcyp Simcypsimulator:

Distributors
Details of distributors of Cypex products are available under the following links:
Europe
America
Asia
Africa

 

Publications
Published data describing the use of our products can be accessed here.

 

Product Information Sheets Online
Data sheets for all products are available for download in Portable Document Format (PDF) from here . They can also be accessed from the individual product pages.

 

Assays
The enzyme assays we use in-house are detailed here.

 

Bactosomes (human CYPs) (References)
Bacterial membranes containing the following human cytochrome P450s coexpressed with human NADPH-cytochrome P450 reductase.
Bactosomes can be used in conjunction with the Simcypsimulator:

CYP1A1
CYP1A2
CYP1B1
CYP2A6
CYP2A13
CYP2B6
CYP2C8
CYP2C9
CYP2C18
CYP2C19
CYP2D6
CYP2E1
CYP2J2
CYP3A4
CYP3A5
CYP3A7
CYP4A11
CYP4F2
CYP4F3
CYP17A1
CYP46A1 NEW!

For the ultimate in convenience, selected CYPs are also available in our new EasyCYP format, offering standard CYP concentration, standard protein concentration, and a standard vial size throughout the range. Further details are available here.


Bactosome Kits contain one vial of each of the five most popular CYPs, together with a free vial of Control Bactosomes.


Details of the results of our in house comparison of Bactosomes with a leading competitor's products are available here.

Data relating to the stability of Bactosomes on repeated freeze / thawing are available here.

Acknowledgement of commercial partners involved in the development of Bactosomes.

Answers to some frequently asked questions about Bactosomes.

 

Bactosomes (beagle dog CYPs)
Bacterial membranes containing the following dog cytochrome P450s coexpressed with dog NADPH-cytochrome P450 reductase.

CYP1A1
CYP1A2
CYP1B1
CYP2B11
CYP2C21
CYP2C41
CYP2D15
CYP3A12
CYP3A26

 

Bactosomes (mouse CYPs)
Bacterial membranes containing the following mouse cytochrome P450s coexpressed with mouse NADPH-cytochrome P450 reductase.

Cyp1b1
Cyp2b10
Cyp3a11

 

Bactosomes (monkey CYPs)
Bacterial membranes containing the following monkey cytochrome P450s coexpressed with human NADPH-cytochrome P450 reductase.

CYP1B1 (rhesus)
CYP2C8 (CYP2C20) (cynomolgus)
CYP2C9 (CYP2C43) (cynomolgus)
CYP2C19 (CYP2C75) (cynomolgus)
CYP2C76 (cynomolgus)
CYP3A4 (CYP3A8) (cynomolgus)
CYP3A5 (cynomolgus)

 

Bactosomes (pig CYPs)
Bacterial membranes containing the following pig cytochrome P450s coexpressed with pig NADPH-cytochrome P450 reductase.

CYP1A2
CYP2C49
CYP2E1
CYP3A39

 

Bactosomes (rat CYPs)
Bacterial membranes containing the following rat cytochrome P450s coexpressed with rat NADPH-cytochrome P450 reductase.

CYP1A2
CYP1B1
CYP2C11
CYP2D4
CYP2D18
CYP3A2
CYP3A9

 

Other human drug-metabolising enzymes
Sulfotransferases
Glutathione S-transferases
Aldehyde oxidase   ALTERED SPECIFICATION JUN. 2012
Aldehyde dehydrogenase
Carboxylesterases   HIGHER ACTIVITY MAY 2013
UDP-glucuronosyltransferases

 

Control preparations
Control Bactosomes
Reductase Bactosomes
Control cytosol

 

Chemicals
Diclofenac/4'-hydroxydiclofenac
Paclitaxel/6alpha-hydroxypaclitaxel
Radiolabelled lauric acid/metabolites
Tolbutamide/metabolites
7-ethoxyresorufin/resorufin
7-benzyloxyquinoline (7BQ)/metabolite
Radiolabelled 7-ethoxycoumarin
MAMC/HAMC
MFC/BFC/HFC
Omeprazole
3-O-methylfluorescein
Tienilic acid
Ketoconazole
Amodiaquine/desethylamodiaquine
Terfenadine
(-)-N-3-benzylphenobarbital
Montelukast sodium
Diethoxyfluorescein (DEF)
S-mephenytoin/4'-hydroxymephenytoin
1'-hydroxymidazolam/4-hydroxymidazolam

 

Antibodies
Anti-rat liver UGT
Anti-human SULT1A3
Control serum


Nosan logoantibodies distributed by Cypex (Europe only):
Anti-human CYP1A1
Anti-human CYP1A2
Anti-human CYP2A6
Anti-human CYP2C8
Anti-human CYP2C9
Anti-human CYP2C19
Anti-human CYP2D6
Anti-human CYP2E1
Anti-human CYP3A4
Control serum

Data obtained using the above antibodies published by Nosan.

Anti-rat CYP1A1
Anti-rat CYP2B1
Anti-rat CYP2C11
Anti-rat CYP3A2
Anti-rat CYP4A1

 

VA logo
Monoclonal antibodies distributed by Cypex.
A complete list can be found here.

 

Services

CYP inhibition screening

Cypex will also undertake work under contract such as drug metabolite synthesis and heterologous protein expression. Contact us for details.

 

 

Important: By purchasing these products from Cypex you accept the standard terms and conditions of supply, details of which are freely available on request.

The following are made under licence from BTG International Ltd (AU730155, EP0914446, US6566108 and other patents pending): all recombinant cytochrome P450 products; 4'-hydroxydiclofenac; 6alpha-hydroxypaclitaxel.

United States Patent Nos. 5,420,027 or 5,240,831, Canada Patent No. 2100245 and other patents pending.






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